AHFS Class:

12:08.08 Antimuscarinics/Antispasmodics

Generic Name

• Scopolamine Hydrobromide

Scopolamine hydrobromide is available in 1-mL multiple-dose vials containing 0.4- and 1-mg/mL concentrations. Also present in the products are methylparaben 0.18% and propylparaben 0.02%. Hydrobromic acid may have been used to adjust the pH.^1(6/06); ⁴

pH

From 3.5 to 6.5.^1(6/06); ⁴

Osmolality

The osmolality of scopolamine hydrobromide 0.5 mg/mL was determined to be 303 mOsm/kg.¹²³³

Scopolamine hydrobromide may be administered subcutaneously, intramuscularly, or intravenously by direct intravenous injection after dilution with sterile water for injection.^1(6/06); ⁴

The product should be stored at controlled room temperature and protected from light.^1(6/06) Scopolamine hydrobromide is stated to be incompatible with alkalies.⁴ Scopolamine hydrobromide decomposition is primarily due to hydrolysis below pH 3 and to both hydrolysis and inversion about the chiral carbon above pH 3. The minimum rate of decomposition occurs at pH 3.5.¹⁰⁷²

Additive Compatibility

Drugs in Syringe Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions March 31, 2024. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.