Methylprednisolone acetate is an injectable suspension that is available in 20-, 40-, and 80-mg/mL concentrations in 5- and 10-mL multiple-dose vials.3875 Each mL contains3875:
| Component | Concentration/mL | ||
|---|---|---|---|
| Methylprednisolone acetate | 20 mg | 40 mg | 80 mg |
| Polyethylene glycol 3350 | 29.5 mg | 29.1 mg | 28.2 mg |
| Polysorbate 80 | 1.97 mg | 1.94 mg | 1.88 mg |
| Monobasic sodium phosphate | 6.9 mg | 6.8 mg | 6.59 mg |
| Dibasic sodium phosphate | 1.44 mg | 1.42 mg | 1.37 mg |
| Benzyl alcohol | 9.3 mg | 9.16 mg | 8.88 mg |
| Sodium chloride | to adjust tonicity | to adjust tonicity | to adjust tonicity |
| Sodium hydroxide and/or hydrochloric acid | qs | qs | qs |
Methylprednisolone acetate is also available at concentrations of 40- and 80-mg/mL in 1-mL single-dose vials.3875 Each mL contains3876:
| Component | Concentration/mL | |
|---|---|---|
| Methylprednisolone acetate | 40 mg | 80 mg |
| Polyethylene glycol 3350 | 29 mg | 28 mg |
| Myristyl-gamma-picolinium chloride | 0.195 mg | 0.189 mg |
| Sodium chloride | to adjust tonicity | to adjust tonicity |
| Sodium hydroxide and/or hydrochloric acid | qs | qs |
pH
From 3.5 to 7.0.3875
Trade Name(s)
Depo-Medrol
Methylprednisolone acetate is administered by intramuscular, intra-articular, intrasynovial, soft tissue, and intralesional injection without dilution.3875 The drug is a suspension that must not be administered intravenously.3875 Care should be taken to avoid injection or leakage into the dermis.3875 Injection into the deltoid muscle should be avoided because of a high incidence of subcutaneous atrophy.3875
The intact vials should be stored at controlled room temperature.3875 Unused portions of single-dose vials should be discarded.3876
For a list of references cited in the text of this monograph, search the monograph titled References.