Pyridoxine hydrochloride is available as a 100-mg/mL solution for injection in 1-mL multiple-dose vials.3965 Each mL contains pyridoxine hydrochloride 100 mg and chlorobutanol 0.5% in water for injection.3965 Sodium hydroxide may have been added to adjust pH.3965 Aluminum also is present.3965
pH
From 2 to 3.8.3965
Aluminum Content
Aluminum content may vary depending on the product; specific product labeling should be consulted.
Pyridoxine hydrochloride injection (Fresenius Kabi) is stated to contain no more than 3150 mcg of aluminum per L.3965
Osmolality
The osmolality of pyridoxine hydrochloride 100 mg/mL was determined to be 870 mOsm/kg by freezing-point depression and 852 mOsm/kg by vapor pressure.1071
Pyridoxine hydrochloride may be administered by intramuscular or intravenous injection.3965
Pyridoxine hydrochloride injection should be stored at controlled room temperature and protected from light.3965
Syringes
Pyridoxine hydrochloride 100 mg/mL was stable for six months at room temperature packaged in 5-, 10-, and 20-mL polypropylene syringes (Becton Dickinson).2692
Sorption
Pyridoxine hydrochloride (Sigma) 40 mg/L did not display significant sorption to a PVC plastic test strip in 24 hours.12
Drugs in Syringe Compatibility
Additional Compatibility Information
Parenteral Nutrition Solutions
The stability of pyridoxine hydrochloride 15 mg/L was studied in representative parenteral nutrition solutions exposed to fluorescent light, indirect sunlight, and direct sunlight for eight hours. One 5-mL vial of multivitamin concentrate (Lyphomed) containing 15 mg of pyridoxine hydrochloride and also 1 mg of folic acid (Lederle) was added to a liter of parenteral nutrition solution composed of amino acids 4.25%-dextrose 25% (Travenol) with standard electrolytes and trace elements. Pyridoxine hydrochloride was stable over the eight-hour study at room temperature under fluorescent light and indirect sunlight. However, eight hours of exposure to direct sunlight caused an 86% loss of pyridoxine hydrochloride.842
The stability of numerous vitamins in parenteral nutrition solutions composed of amino acids (Kabi-Vitrum), dextrose 30%, and lipid emulsion 20% (Kabi-Vitrum) in a 2:1:1 ratio with electrolytes, trace elements, and both fat- and water-soluble vitamins was reported. The admixtures were stored in darkness at 2 to 8°C for 96 hours with no significant loss of pyridoxine hydrochloride.1225
The vitamins in Cernevit (Baxter) diluted in three 2-in-1 parenteral nutrition admixtures were tested for stability over 48 hours. Most of the other vitamins, including pyridoxine hydrochloride, retained their initial concentrations.2796
For a list of references cited in the text of this monograph, search the monograph titled References.