Sodium acetate is available as a 2-mEq/mL concentrate for injection in 20-mL single-dose vials and 50- or 100-mL pharmacy bulk packages.3790; 3791 Each mL of the 2-mEq/mL concentrate contains 164 mg of sodium acetate in water for injection with acetic acid to adjust pH.3790
Sodium acetate is also available as a 4-mEq/mL concentrate for injection in 100-mL pharmacy bulk packages.3792 Each mL of the 4-mEq/mL concentrate contains 328 mg of sodium acetate in water for injection with acetic acid to adjust pH.3792
pH
Osmolarity
The 2-mEq/mL concentrate has a calculated osmolarity of 4000 mOsm/L, and the 4-mEq/mL concentrate has a calculated osmolarity of 8000 mOsm/L.3790; 3792
Sodium acetate is administered by slow intravenous infusion only after dilution in a larger volume of fluid.3790; 3792 The concentrate for injection must not be administered undiluted.3790; 3792
Sodium acetate concentrate for injection is a clear solution.3790; 3792 Intact vials should be stored at controlled room temperature.3790; 3791; 3792
Unused portions of single-dose vials should be discarded.3790 Once the closure of the pharmacy bulk vial has been penetrated with a suitable sterile dispensing set or transfer device, the vial should not be re-entered and dispensing from the vial should be completed within 4 hours.3791; 3792 Any unused portion should be discarded after 4 hours of initial vial entry.3791; 3792
Diluted solutions prepared from pharmacy bulk containers should be stored under refrigeration and used within 24 hours.3791; 3792
For a list of references cited in the text of this monograph, search the monograph titled References.