Alfentanil hydrochloride is available as a 500-mcg/mL preservative-free solution in 2-, 5-, 10-, and 20-mL ampuls.3953 Each mL of solution contains alfentanil hydrochloride equivalent to 500 mcg of alfentanil base in water for injection with sodium chloride for isotonicity.3953
pH
From 4 to 6.3953
Osmolality
Alfentanil hydrochloride injection is isotonic.3953
Trade Name(s)
Alfenta
Alfentanil hydrochloride is administered by intravenous injection or infusion.3953 Induction doses, administered by intravenous injection, should be given slowly (e.g., over 3 minutes).3953 For infusion, 20 mL of alfentanil hydrochloride injection may be added to 230 mL of diluent to provide a final solution containing alfentanil 40 mcg/mL.3953
Intact containers should be stored at controlled room temperature and protected from light.3953
Syringes
Alfentanil hydrochloride (Janssen) 0.5 mg/mL in dextrose 5% was packaged in 20-mL polypropylene syringes (Becton Dickinson) and stored at 20°C exposed to light and at 8°C for 16 weeks. The solutions were visually clear and colorless throughout the study. No loss of alfentanil hydrochloride occurred and no leached substances from the plastic syringes appeared.2191
Alfentanil hydrochloride (Janssen) 0.167 mg/mL in sodium chloride 0.9% in polypropylene syringes (Sherwood) was physically stable and exhibited little loss in 24 hours stored at 4 and 23°C.2191
Sorption
Alfentanil hydrochloride (Janssen) (concentration unspecified) was found to be compatible with polyethylene, polypropylene, and polyvinyl chloride (PVC).2468
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