Pancuronium bromide is available in 2- and 5-mL vials containing 2 mg/mL of drug.2871 It is also available in 10-mL vials at a concentration of 1 mg/mL.2871; 2872 Each mL (Hospira) also contains sodium acetate anhydrous 1.2 mg, benzyl alcohol 1%, and sodium chloride to adjust for isotonicity.2872 Each mL (Teva) also contains sodium acetate anhydrous 2 mg, benzyl alcohol 1%, sodium chloride 4 mg for isotonicity, and water for injection.2871 Acetic acid and/or sodium hydroxide is added to adjust the pH.2871; 2872
pH
The solution has been adjusted to pH 3.8 to 4.2 by the manufacturer.2871; 2872
Osmolality
The osmolality of pancuronium bromide (Organon) 1 mg/mL was determined to be 277 mOsm/kg by freezing-point depression and 273 mOsm/kg by vapor pressure.1071
The osmolality of pancuronium bromide 2 mg/mL was determined to be 338 mOsm/kg.1233
Pancuronium bromide should be stored under refrigeration at 2 to 8°C.2871; 2872 However, the manufacturer indicates that the drug is stable for 6 months at room temperature.853; 1181; 1433; 2871; 2872
Sorption
The manufacturer indicates that pancuronium bromide in compatible infusion solutions does not undergo sorption to glass or plastic containers during short-term storage over 48 hours.2871; 2872 However, the drug may exhibit sorption to plastic containers with prolonged contact.4
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