Hyaluronidase is supplied as a 150-unit/mL solution in 1-mL fill vials. Each mL also contains sodium chloride 8.5 mg, edetate disodium 1 mg, calcium chloride 0.4 mg, and thimerosal not more than 0.1 mg in sodium phosphate buffer.1(11/05)
pH
From 6.4 to 7.4.4
Osmolality
From 295 to 355 mOsm/kg.1(11/05)
Trade Name(s)
Amphadase
Hyaluronidase is administered subcutaneously, intradermally, or intramuscularly along with other drugs or solutions. The solutions should be isotonic for subcutaneous administration. It should not be administered intravenously.1(11/05); 4
Hyaluronidase injection in intact vials should be stored under refrigeration at 2 to 8°C. It should not be used if it is discolored or contains a precipitate.4
Hyaluronidase (Wyeth) 75 units/mL in citric acid/sodium citrate buffer (pH 4.5) was found to lose about 7 to 8% activity in 24 hours at 4 and 23°C. Hyaluronidase activity decreased by 25 to 33% in 48 hours.1907
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