AHFS Class:

10:00 Antineoplastic Agents

Oxaliplatin is available as a 5-mg/mL concentrate for injection in 10-, 20-, or 40-mL single-dose vials containing 50, 100, or 200 mg of oxaliplatin, respectively, in water for injection.²⁸⁵²; ²⁸⁵³ Some products may contain lactose monohydrate as an excipient.²⁸⁵²

Oxaliplatin is also available as a lyophilized powder in single-dose vials containing 50 or 100 mg of oxaliplatin with lactose monohydrate as an excipient.²⁸⁵⁴ Reconstitute the 50- or 100-mg vials with 10 or 20 mL, respectively, of water for injection or dextrose 5%.²⁸⁵⁴ Reconstituted solutions must be further diluted prior to administration.²⁸⁵⁴

pH

Concentrate for injection: 4 to 6.²⁸⁵²

Trade Name(s)

Eloxatin

For intravenous infusion, both the concentrate for injection and the reconstituted solution must be diluted in 250 to 500 mL of dextrose 5% prior to administration.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴ Sodium chloride or other chloride-containing solutions must not be used for reconstitution²⁸⁵⁴ or dilution.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴ Solutions should be visually inspected prior to administration; discard if particulate matter and discoloration is present.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴

Oxaliplatin is administered by intravenous infusion over 2 hours.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴ The infusion line should be flushed with dextrose 5% prior to administering any other medication.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴

Aluminum has been reported to cause degradation of platinum compounds; do not use needles or administration sets containing aluminum parts for the preparation or mixing of oxaliplatin injection.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴

Intact vials of the concentrate or lyophilized powder should be stored at controlled room temperature.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴ The concentrate for injection should be protected from light and stored in the outer carton; do not freeze.²⁸⁵²; ²⁸⁵³

The lyophilized powder formulation is not light sensitive.²⁸⁵⁴ Reconstituted solutions may be stored up to 24 hours at 2 to 8°C.²⁸⁵⁴ Diluted solutions of either formulation are stated to be stable for 6 hours at room temperature (20 to 25°C) or up to 24 hours at 2 to 8°C and do not require light protection.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴ However, one manufacturer has stated that oxaliplatin diluted in dextrose 5% for infusion was stable for 24 hours at room temperature; at a concentration of 3 g/L, the drug was stated to be stable for at least five days at room temperature.²⁶²³

pH Effects

Oxaliplatin is incompatible with alkaline drugs and solutions and should not be mixed with or administered simultaneously with them.²⁸⁵²; ²⁸⁵³; ²⁸⁵⁴

Solution Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

Additional Compatibility Information

Infusion Solutions

Stability of oxaliplatin (Accord) 0.1 mg/mL in dextrose 5% (Braun), sodium chloride 0.9% (Braun), Ringer’s injection, lactated (Braun), Dianeal PD-4 with dextrose 1.36% (Baxter), and phosphate buffer (pH 7.4) 0.14 M at 42°C was evaluated for use of the drug as hyperthermic intraperitoneal chemotherapy.³⁵²⁴ Less than 10% oxaliplatin loss occurred in 2 hours in dextrose 5%.³⁵²⁴ In phosphate buffer and Dianeal PD-4 with dextrose 1.36%, drug losses of less than 10% occurred within 30 minutes; however, losses exceeded 10% by 2 hours.³⁵²⁴ In Ringer’s injection, lactated and sodium chloride 0.9%, the solutions with the greatest chloride ion concentrations, drugs losses exceeded 10% as early as 30 minutes and losses of 18 and 21%, respectively, occurred within 2 hours.³⁵²⁴

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions June 30, 2026. © Copyright, 2026. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.