Tramadol hydrochloride is available as a 50-mg/mL injection solution in 1- and 2-mL (50- and 100-mg) ampuls.4065; 4066 Sodium acetate and water for injection are also present in the formulation.4065; 4066
Trade Name(s)
Contramal, Topalgic, Tramal, Zamadol, Zydol
Tramadol hydrochloride is administered intramuscularly, by direct intravenous injection slowly over 2 to 3 minutes,4065; 4066 or by intravenous infusion after dilution.4065
Tramadol hydrochloride injection is a clear, colorless solution.4065 Intact ampuls should be stored below 30°C.4065; 4066 Product labeling may state to protect from light.4066
Exposure to or protection from light did not affect the stability of tramadol hydrochloride 0.5- and 4-mg/mL infusion solutions in dextrose 5% or sodium chloride 0.9%.434
Freezing Solutions
Tramadol hydrochloride (Searle) 1 mg/mL in dextrose 5% in polyvinyl chloride (PVC) bags was stored frozen at -20°C for 120 days, microwave thawed, and stored refrigerated at 4°C for 60 days. No visual changes and 5% loss of tramadol hydrochloride was found.2450; 2526
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