AHFS Class:

56:22.20 5-HT3 Receptor Antagonists

Palonosetron is available as a 50-mcg/mL solution in 5-mL (0.25-mg) and 1.5-mL (0.075-mg) single-use vials containing palonosetron hydrochloride equivalent to palonosetron as the free base.²⁸⁷⁰ Each mL of solution also contains mannitol 41.5 mg, disodium edetate, and citrate buffer in water for injection.²⁸⁷⁰

Equivalency

Palonosetron hydrochloride 0.28 mg is equivalent to 0.25 mg of palonosetron as the free base.²⁸⁷⁰

pH

From 4.5 to 5.5.²⁸⁷⁰

Tonicity

Palonosetron hydrochloride injection is isotonic.²⁸⁷⁰

Trade Name(s)

Aloxi

Palonosetron hydrochloride injection is administered intravenously without dilution.²⁸⁷⁰

In adults, a dose should be administered over 10 or 30 seconds, depending upon the indication.²⁸⁷⁰ Pediatric doses should be infused over 15 minutes.²⁸⁷⁰

The manufacturer states that the infusion line should be flushed with sodium chloride 0.9% prior to and following administration of palonosetron hydrochloride injection.²⁸⁷⁰

Palonosetron hydrochloride injection is a clear, colorless solution.²⁸⁷⁰ Intact vials of palonosetron hydrochloride injection should be stored at controlled room temperature and should be protected from light and freezing.²⁸⁷⁰

Palonosetron hydrochloride injection should be visually inspected for particulate matter or discoloration prior to administration.²⁸⁷⁰

Solution Compatibility

Additive Compatibility

Drugs in Syringe Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions January 15, 2023. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.