AHFS Class:

40:08 Alkalinizing Agents

Generic Name

• Sodium Lactate

Sodium lactate additive solution is available as a 5-mEq/mL concentrate for injection in 10-mL single-dose vials.³⁸⁵⁷ Each 10-mL vial contains 5.6 g of sodium lactate anhydrous (50 mEq each of sodium and lactate ion) in water for injection with hydrochloric acid for pH adjustment.³⁸⁵⁷

pH

The pH of a M solution in water for injection ranges from 6 to 7.3.³⁸⁵⁷

Osmolarity

The calculated osmolarity of the concentrate is approximately 10,000 mOsm/L.³⁸⁵⁷

Osmolality

The osmolality was determined to be 11,490 mOsm/kg by freezing-point depression and 10,665 mOsm/kg by vapor pressure.¹⁰⁷¹

Sodium lactate additive solution is administered by intravenous infusion only after dilution in a larger volume of fluid.³⁸⁵⁷ The appropriate volume of the concentrate may be added to infusion solutions to provide the desired number of milliequivalents of lactate ion with an equal number of milliequivalents of sodium ion.³⁸⁵⁷ A M (1.9%) solution may be prepared by diluting 50 mEq of the additive solution in 290 mL of a nonelectrolyte solution or sterile water for injection; the resulting solution is approximately isotonic and contains 167 mEq/L each of lactate and sodium ion in 300 mL.³⁸⁵⁷

Intact containers of sodium lactate additive solution should be stored at controlled room temperature.³⁸⁵⁷

Solution Compatibility

Additive Compatibility

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions March 31, 2023. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.