Salbutamol sulfate injection is available as a solution in 1-mL ampuls.3598; 3600 Each mL contains 500 mcg of salbutamol as the sulfate, as well as sodium chloride, sodium hydroxide, and sulfuric acid in water for injection.3598; 3600
Salbutamol sulfate also is available as a concentrate for injection in 5-mL ampuls for use in infusions following dilution.3599; 3600 Each mL contains 1 mg of salbutamol as the sulfate, as well as sodium chloride, sodium hydroxide, and sulfuric acid in water for injection.3599; 3600 This concentrate for injection must be diluted in a suitable infusion solution prior to administration.3599; 3600
pH
The pH of both the injection and the concentrate for injection (GlaxoSmithKline New Zealand) is adjusted to 3.5.3600
Tonicity
Both salbutamol sulfate injection and concentrate for injection are isotonic.3598; 3599; 3600
Trade Name(s)
Salbumol, Ventolin
Salbutamol sulfate injection is administered by subcutaneous, intramuscular, or slow intravenous injection.3598; 3600 A 50-mcg/mL salbutamol concentration (e.g., 250 mcg diluted in 5 mL) is suitably dilute for slow intravenous injection; the 500-mcg/mL concentration has been diluted with sterile water for injection to achieve the 50-mcg/mL concentration.3598; 3600
Salbutamol sulfate concentrate for injection is used to prepare intravenous infusion solutions of the drug; it should not be administered undiluted.3599; 3600 The concentrate for injection should be diluted to a concentration of 10, 20, or 200 mcg/mL, depending upon the indication and infusion method (e.g., syringe pump), with a compatible infusion solution.3599; 3600 Recommended infusion solutions may vary based on the indication; consult specific labeling for details.3598; 3599; 3600
Salbutamol sulfate injection and concentrate for injection are clear, colorless or pale straw-colored solutions.3598; 3599; 3600 The intact containers should be stored below 30°C and protected from light (e.g., by storing in the outer container).3598; 3599; 3600
Syringes
Salbutamol sulfate (GlaxoSmithKline) prepared at a salbutamol concentration of 3 mg/50 mL in sodium chloride 0.9% in a 50-mL polypropylene syringe (Becton Dickinson) was physically stable for 48 hours at room temperature.3545
Salbutamol sulfate (GlaxoSmithKline) prepared at a salbutamol concentration of 0.06 mg/mL in sodium chloride 0.9% in a 50-mL polypropylene syringe (Becton Dickinson) was physically and chemically stable for 30 days at 2 to 8°C protected from light.3601
Drugs in Syringe Compatibility
Y-Site Injection Compatibility (1:1 Mixture)
Additional Compatibility Information
Infusion Solutions
Manufacturers state that recommended diluents for salbutamol sulfate are limited to sodium chloride (concentration unspecified), sodium chloride and dextrose (concentrations unspecified), dextrose (concentration unspecified), and sterile water for injection.3598; 3599; 3600
For a list of references cited in the text of this monograph, search the monograph titled References.