AHFS Class:

56:22.08 Antihistamines

Generic Name

• Cyclizine Lactate (CAS Registry Number: 5897-19-8)

Cyclizine lactate is available in 1-mL ampuls containing 50 mg of drug in water for injection.³⁸; ¹¹⁵

pH

From 3.3 to 3.7.¹⁷⁶

Trade Name(s)

Valoid

Cyclizine lactate is administered by intramuscular or intravenous injection. When administered intravenously, it should be injected slowly, with minimal withdrawal of blood in the syringe.³⁸; ¹¹⁵

Cyclizine lactate injection, a colorless solution, should be stored below 25°C and protected from light.³⁸; ¹¹⁵

Crystallization

Cyclizine lactate has an aqueous solubility of 8 mg/mL. When the drug was diluted to concentrations of 7.5 and 3.75 mg/mL in water or dextrose 5%, it remained in solution for at least 24 hours at 23°C. However, when these dilutions were made with sodium chloride 0.9%, crystals formed within 24 hours at 23°C.¹⁷⁶¹

Additive Compatibility

Drugs in Syringe Compatibility

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions March 7, 2025. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.