AHFS Class:

36:68 Roentgenographic and Other Imaging Agents

Generic Name

• Iopamidol

Iopamidol is available as a injection solution intended for either intravascular or intrathecal use.²⁷⁵⁷; ³⁰⁰⁹ Iopamidol for intravascular use is available in concentrations of 200, 250, 300, or 370 mg/mL of organically bound iodine (mg I/mL) equivalent to 408 (41%), 510 (51%), 612 (61%), or 755 (76%) mg/mL, respectively, of iopamidol in vial or bottle sizes ranging from 30 to 200 mL; not all concentrations are available in all sizes.²⁷⁵⁷ The 300- and 370-mg I/mL concentrations also are available in 200- and 500-mL imaging bulk packages.²⁹¹⁶ Iopamidol for intrathecal use (Isovue-M) is available in concentrations of 200 mg I/mL (iopamidol 41%) in 10-mL vials and 300 mg I/mL (iopamidol 61%) in 15-mL vials.³⁰⁰⁹ Also present in each mL are tromethamine 1 mg and edetate calcium disodium, with hydrochloric acid and/or sodium hydroxide to adjust the pH.²⁷⁵⁷; ³⁰⁰⁹ Table 1 presents the characteristics of iopamidol products.

Table 1. Iopamidol Product Characteristics²⁷⁵⁷; ³⁰⁰⁹

pH

6.5 to 7.5.²⁷⁵⁷; ³⁰⁰⁹

Trade Name(s)

Isovue, Isovue-M

Depending on the specific product, iopamidol may be administered intravenously, intra-arterially, or intrathecally, preferably at body temperature.²⁷⁵⁷; ³⁰⁰⁹ Extravasation should be avoided.²⁷⁵⁷ Intrathecal injection should be made slowly over 1 to 2 minutes.³⁰⁰⁹

Iopamidol injection is a colorless to pale yellow solution.²⁷⁵⁷; ³⁰⁰⁹ Intact containers should be stored at controlled room temperature and protected from light.²⁷⁵⁷; ³⁰⁰⁹ Products with any signs of crystallization should be discarded.²⁷⁵⁷; ³⁰⁰⁹

Withdrawal of contents from imaging bulk packages should be completed within of 10 hours of initial closure entry.²⁹¹⁶ Any unused portions should be discarded after 10 hours.²⁹¹⁶ After closure entry, the temperature of the container should not exceed 25°C; it is preferable to warm the dose to body temperature prior to administration.²⁹¹⁶

Drugs in Syringe Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions October 1, 2012. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.