Telavancin hydrochloride is available as a lyophilized powder in single-use vials containing telavancin 250 and 750 mg as the hydrochloride.2831 Also present are hydroxypropyl-beta-cyclodextrin, mannitol, and sodium hydroxide and hydrochloric acid to adjust pH.2831
The 250-mg vial should be reconstituted with 15 mL and the 750-mg vial with 45 mL of dextrose 5%, sterile water for injection, or sodium chloride 0.9% and mixed thoroughly to yield a telavancin concentration of 15 mg/mL.2831 To minimize foaming during reconstitution, allow the vacuum of the vial to draw the diluent from the syringe into the vial; do not forcefully inject the diluent.2831 Any vial that does not have a vacuum should be discarded.2831 Dissolution may occasionally require up to 20 minutes.2831 Do not forcefully shake the vial or the diluted solution in the infusion bag.2831
pH
From 4 to 5.2831
Trade Name(s)
Vibativ
Telavancin is administered by intravenous infusion over 60 minutes after dilution in a compatible infusion solution.2831 For telavancin doses of 150 to 800 mg, dilution in 100 to 250 mL is recommended.2831 For doses outside this range, dilution to a concentration of 0.6 to 8 mg/mL is recommended.2831 The manufacturer recommends dilution in dextrose 5%; sodium chloride 0.9%; or Ringer’s injection, lactated.2831
Intact vials of telavancin hydrochloride should be stored under refrigeration.2831 The reconstituted drug in the vial and the diluted solution in the infusion bag should be used within 12 hours if stored at room temperature or 7 days if stored under refrigeration.2831; 3097 The total time for the reconstituted drug in the vial and the diluted solution in the infusion bag together should not exceed 12 hours at room temperature or 7 days under refrigeration.2831; 3097
Freezing Solutions
The manufacturer states that the diluted solution of telavancin in the infusion bag can be stored at -30 to -10°C for up to 32 days.2831 Telavancin (Ben Venue) 0.6 and 8 mg/mL diluted in sodium chloride 0.9% or dextrose 5% in polyvinyl chloride (PVC) and non-PVC infusion bags and stored at -20°C exhibited less than 10% loss of the drug during the 32-day study period.3096 The authors recommended that solutions be brought to room temperature without any assistance (e.g., sonication, hot water bath) and used immediately after thawing, or within 12 hours at room temperature; thawed solutions should not be refrozen.3096
For a list of references cited in the text of this monograph, search the monograph titled References.