Anidulafungin is available in 50-mg vials with 50 mg of fructose, 250 mg of mannitol, 125 mg of polysorbate 80, 5.6 mg of tartaric acid, and sodium hydroxide and/or hydrochloric acid to adjust pH.2862 Anidulafungin also is available in 100-mg vials with 100 mg of fructose, 500 mg of mannitol, 250 mg of polysorbate 80, 11.2 mg of tartaric acid, and sodium hydroxide and/or hydrochloric acid to adjust pH.2862
Reconstitute the 50- and 100-mg vials with 15 and 30 mL, respectively, of sterile water for injection to yield a concentrated solution containing anidulafungin 3.33 mg/mL.2862 This concentrate must be diluted in dextrose 5% or sodium chloride 0.9% for administration.2862 The manufacturer recommends diluting 50-, 100-, and 200-mg quantities of anidulafungin in 50, 100, and 200 mL, respectively.2862
Trade Name(s)
Eraxis
Anidulafungin is administered by intravenous infusion at a rate not exceeding 1.1 mg/min after dilution in dextrose 5% or sodium chloride 0.9%.2862 No other solution should be used.2862
Intact vials of anidulafungin should be stored refrigerated and protected from freezing.2862
The reconstituted anidulafungin solution is stable at controlled room temperature for up to 24 hours prior to dilution.2862 Anidulafungin diluted in dextrose 5% or sodium chloride 0.9% for infusion is stable at controlled room temperature for up to 48 hours or frozen for up to 72 hours from preparation.2862
Y-Site Injection Compatibility (1:1 Mixture)
Additional Compatibility Information
Peritoneal Dialysis Solutions
Anidulafungin (Ecalta, Pfizer) 100 mg/L was visually compatible in both Dianeal PD-4 with dextrose 1.36% (Baxter) and Extraneal with icodextrin 7.5% (Baxter) peritoneal dialysis solutions at 4 and 25°C for up to 14 days in polyvinyl chloride (PVC) containers; however, cloudiness developed after 24 hours in the same solutions stored at 36°C.3419
For a list of references cited in the text of this monograph, search the monograph titled References.