AHFS Class:

28:20.32 Respiratory and CNS Stimulants

Caffeine citrate injection is available as a 20-mg/mL solution in 3-mL preservative-free, single-dose vials containing 60 mg of caffeine citrate.³⁹¹⁵ Each mL of solution contains caffeine citrate 20 mg prepared from caffeine anhydrous 10 mg with citric acid monohydrate 5 mg and sodium citrate dihydrate 8.3 mg in water for injection.³⁹¹⁵

Equivalency

Caffeine citrate 20 mg is equivalent to 10 mg of caffeine base.³⁹¹⁵

pH

Adjusted to 4.7.³⁹¹⁵

Trade Name(s)

Cafcit

Caffeine citrate injection is administered undiluted by slow intravenous injection using a syringe pump over 30 minutes as a loading dose and over 10 minutes as a maintenance dose.³⁹¹⁵

Caffeine citrate injection is a clear, colorless solution.³⁹¹⁵ Intact vials should be stored at controlled room temperature.³⁹¹⁵

Syringes

Caffeine (salt form unspecified) 10 mg/mL was repackaged in glass and plastic syringes (Becton Dickinson) and stored at room temperature and 4°C. Less than 4% loss occurred over 60 days.¹³⁹

Caffeine citrate injection at a caffeine concentration of 10 mg/mL (Sabex) was repackaged in 1-mL polypropylene syringes (Becton Dickinson) capped with polyolefin tip caps (Monoject) and stored at 20.5 to 22.5°C under fluorescent light.³⁹¹⁶ No color change or precipitation was observed and no loss of drug occurred over 180 days.³⁹¹⁶

Solution Compatibility

Drugs in Syringe Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions July 5, 2023. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.