Minocycline hydrochloride is available as a yellow to amber lyophilized powder in single-use vials containing the equivalent of 100 mg of minocycline with 269 mg of magnesium sulfate heptahydrate (2.2 mEq of magnesium) and sodium hydroxide to adjust the pH.3226
The 100-mg vial should be reconstituted with 5 mL of sterile water for injection to yield a solution containing minocycline 20 mg/mL.3226; 3269 The reconstituted solution should be further diluted immediately in 100 to 1000 mL of dextrose 5%, dextrose 5% in sodium chloride 0.9%, or sodium chloride 0.9%; alternatively, the reconstituted solution may be diluted in 250 to 1000 mL of Ringer’s injection, lactated (see Stability).3226; 3232
pH
The pH of the reconstituted solution ranges from 4.5 to 5.3226 When diluted in a compatible infusion solution, the pH usually ranges from 4.5 to 6.3226
Trade Name(s)
Minocin
Minocycline hydrochloride is administered by intravenous infusion over 60 minutes following dilution in a compatible infusion solution.3226 If a common infusion line is being used to administer other drugs in addition to minocycline hydrochloride, the line should be flushed with a compatible infusion solution prior to and following infusion of minocycline.3226
Intact vials should be stored at controlled room temperature.3226
Upon dilution in an infusion bag containing a compatible solution, minocycline is stable for up to 4 hours at room temperature or up to 24 hours at 2 to 8°C.3226
Although minocycline hydrochloride is noted to be stable at certain concentrations in Ringer’s injection, lactated, the drug should not be mixed with other calcium-containing solutions, especially neutral or alkaline solutions, due to the potential for precipitation.3226 Unused portions should be discarded.3226
pH Effects
A precipitate may form if minocycline hydrochloride is diluted in neutral or alkaline solutions.3226
For a list of references cited in the text of this monograph, search the monograph titled References.