AHFS Class:

28:08.04.04 Reversible COX-1/COX-2 Inhibitors

Generic Name

• Ibuprofen

Ibuprofen is available as a 100-mg/mL concentrate for injection in single-dose vials containing 800 mg of the drug.³⁵³⁴ Each mL of the concentrate for injection also contains 78 mg of arginine in water for injection.³⁵³⁴ CAUTION: Care should be taken to ensure that the correct drug product, dose, and administration procedures are used and that no confusion with other products (e.g., ibuprofen lysinate [NeoProfen]) occurs.

The concentrate for injection must be diluted in a compatible diluent prior to administration.³⁵³⁴ The concentrate for injection should be diluted to a final concentration of 4 mg/mL or less in sodium chloride 0.9%, dextrose 5%, or Ringer’s injection, lactated.³⁵³⁴ For fixed doses of 100, 200, and 400 mg, the manufacturer recommends dilution in at least 100 mL; for fixed doses of 800 mg, the manufacturer recommends dilution in at least 200 mL.³⁵³⁴ For patients requiring weight-based dosing (e.g., some pediatric patients), the drug should be diluted to a concentration of 4 mg/mL or less.³⁵³⁴

Ibuprofen also is available as 4-mg/mL iso-osmotic, ready-to-use solution for infusion in single-dose flexible polypropylene bags containing 800 mg of the drug.³⁵³⁴ The solution also contains sodium phosphate, sodium hydroxide, and sodium chloride in water for injection.³⁵³⁴ The ready-to-use solution for infusion is for use only in those for whom ibuprofen doses of 800 mg are intended.³⁵³⁴

pH

The pH of both the concentrate for injection and the ready-to-use 4-mg/mL solution for infusion is approximately 7.4.³⁵³⁴

Trade Name(s)

Caldolor

Ibuprofen injection is intended only for intravenous administration.³⁵³⁴ Solutions of ibuprofen at concentrations of 4 mg/mL or less are administered by intravenous infusion over at least 30 minutes in adults and over at least 10 minutes in pediatric patients.³⁵³⁴

Both the concentrate for injection and the ready-to-use solution for infusion are clear and colorless.³⁵³⁴ Intact vials and bags should be stored at controlled room temperature.³⁵³⁴ Unused portions should be discarded.³⁵³⁴

Solution Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions December 5, 2024. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.