Tropisetron hydrochloride is available as an aqueous solution in 2- and 5-mL ampuls. Each mL of solution provides 1 mg of tropisetron (present as 1.13 mg of the hydrochloride). Also present in the formulation are acetic acid, sodium acetate, sodium chloride, and water for injection.38; 115
Trade Name(s)
Navoban
Tropisetron hydrochloride is administered either as a slow intravenous injection over not less than 30 seconds for a 2-mg dose38; 115 or 1 minute for a 5-mg dose115 or as an intravenous infusion over 15 minutes.38
Tropisetron hydrochloride injection is a colorless or faintly brown-yellow solution. Intact ampuls should be stored at room temperature.38
Syringes
Tropisetron hydrochloride (Sandoz) 1 mg/mL was packaged in polypropylene syringes (Becton Dickinson) and stored under refrigeration at 4°C and at room temperature (about 23°C) exposed to daylight and protected from light for 15 days. About 4% loss of tropisetron hydrochloride occurred in 15 days under any of the storage conditions.2298
Sorption
The manufacturer indicates that tropisetron hydrochloride solutions are compatible with both glass and PVC containers and infusion sets.38
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