AHFS Class:

90:28.04.92 Polyclonal Antibodies, Miscellaneous

Antithymocyte globulin (rabbit) is available as a lyophilized powder in preservative-free single-dose vials containing 25 mg of antithymocyte globulin (rabbit) with glycine 50 mg, mannitol 50 mg, and sodium chloride 10 mg.⁴⁰²⁸

Allow vials to reach room temperature before reconstitution.⁴⁰²⁸ Reconstitute each vial with 5 mL of sterile water for injection, rotating the vial gently until powder is completely dissolved.⁴⁰²⁸ The reconstituted solution contains approximately 5 mg/mL antithymocyte globulin (rabbit), of which over 90% is rabbit gamma immune globulin (IgG).⁴⁰²⁸ Inspect for particulate matter after reconstitution; should some particulate matter remain, continue rotating the vial gently until no particulate matter is visible.⁴⁰²⁸ Discard the solution if particulate matter persists.⁴⁰²⁸

The reconstituted solution should be further diluted in a compatible infusion solution (saline or dextrose) prior to administration.⁴⁰²⁸ The manufacturer recommends that each vial to be administered be diluted in 50 mL of infusion solution.⁴⁰²⁸ The total volume usually ranges between 50 and 500 mL.⁴⁰²⁸ Invert the bag gently once or twice to mix the solution before administration.⁴⁰²⁸

pH

Reconstituted solution: 6.5 to 7.2.⁴⁰²⁸

Trade Name(s)

Thymoglobulin

Antithymocyte globulin (rabbit) is administered intravenously into a high-flow vein after reconstitution and dilution in a compatible infusion solution.⁴⁰²⁸

The diluted solution for infusion should be administered through a 0.22-µm filter over a minimum of 6 hours for the first infusion and over at least 4 hours subsequently.⁴⁰²⁸

Intact vials should be stored at 2 to 8°C.⁴⁰²⁸ Protect from light.⁴⁰²⁸ Do not freeze.⁴⁰²⁸

Reconstituted solutions are stated to be stable for up to 24 hours at room temperature; however, room temperature storage is not recommended.⁴⁰²⁸

Diluted solutions should be used immediately; any unused portions should be discarded.⁴⁰²⁸

Sorption

The manufacturer states that no interaction of antithymocyte globulin (rabbit) with glass bottles or PVC bags or administration sets has been found.⁴

Filtration

Diluted solutions for infusion should be administered through a 0.22-µm filter.⁴⁰²⁸

Additive Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions December 5, 2024. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.