Ciprofloxacin is available as a ready-to-use solution in single-dose 100- or 200-mL polyvinyl chloride (PVC) containers containing ciprofloxacin 200 or 400 mg, respectively.3832 Each mL contains 2 mg of ciprofloxacin with dextrose 5%, lactic acid as a solubilizer, and hydrochloric acid to adjust the pH.3832
pH
From 3.5 to 4.6.3832
Trade Name(s)
Cipro I.V.
Ciprofloxacin ready-to-use solution is administered by intravenous infusion over 60 minutes.3832 Slow infusion into a larger vein is recommended to reduce the risk of venous irritation and discomfort.3832
Ciprofloxacin is a clear, colorless to slightly yellow solution.3832 Intact containers should be stored at controlled room temperature or refrigerated at 2 to 8°C and protected from light and freezing.3832
pH Effects
Substantial loss of ciprofloxacin content in admixtures with a pH over 6 has been reported.1924
Light Effects
Ciprofloxacin undergoes slow degradation when exposed to natural daylight. Exposure to mixed natural daylight and fluorescent light resulted in about 2% loss after 12 hours of exposure and about 9% loss after about 96 hours of exposure.2399
Central Venous Catheter
Ciprofloxacin (Bayer) 1 mg/mL in dextrose 5% was found to be compatible with the ARROWg+ard Blue Plus (Arrow International) chlorhexidine-bearing triple-lumen central catheter. Essentially complete delivery of the drug was found with little or no drug loss occurring. Furthermore, chlorhexidine delivered from the catheter remained at trace amounts with no substantial increase due to the delivery of the drug through the catheter.2335
Drugs in Syringe Compatibility
Y-Site Injection Compatibility (1:1 Mixture)
Additional Compatibility Information
Peritoneal Dialysis Solutions
Ciprofloxacin 25 mg/L in Dianeal 137 peritoneal dialysis solution exhibited little or no loss after 42 days at 4, 22, and 37°C when protected from light.1585 At 37°C over 48 hours, losses of up to 10% occurred in Dianeal PD-1 with dextrose 1.5%; losses of up to 7% occurred in Dianeal PD-1 with dextrose 4.5%.1826 Ciprofloxacin 25 and 50 mg/L in Dianeal PD-2 with dextrose 1.5, 2.5, and 4.25% and Extraneal, all solutions both with and without heparin, were found to be stable for 4 days at 38°C.2686
Ciprofloxacin (Meiji Seika) 47.62 mg/L was tested in the following peritoneal dialysis solutions: Extraneal with icodextrin 7.5% (Baxter), Nutrineal with 1.1% amino acids (Baxter), Physioneal 40 with 1.36% dextrose (Baxter), Physioneal 40 with 2.27% dextrose (Baxter), and Physioneal 40 with 3.86% dextrose (Baxter).3833 For the 2-compartment Physioneal solutions, ciprofloxacin was added to the low-pH compartment and the compartments were combined immediately, resulting in a ciprofloxacin concentration of 47.62 mg/L.3833 All solutions were stored at 6°C for 14 days, 25°C for 14 days, or 37°C for 24 hours, protected from light.3833
All solutions were stable (i.e., less than 10% loss of ciprofloxacin concentration) for 14 days at 6°C and for 24 hours at 37°C.3833 At 25°C, ciprofloxacin was stable for 7 days in Extraneal or Nutrineal or for 48 hours in Physioneal 2.27% or Physioneal 3.86%; however, over 10% loss of ciprofloxacin concentration occurred within 6 hours in Physioneal 1.36%.3833
For a list of references cited in the text of this monograph, search the monograph titled References.