Fluconazole is available as a 2-mg/mL solution for intravenous infusion in 50-, 100-, or 200-mL single-dose flexible plastic containers containing fluconazole 100, 200, or 400 mg, respectively.3940; 3941 Each mL of solution contains fluconazole 2 mg and sodium chloride 9 mg in water.3940
pH
Fluconazole infusion solution has a pH of 4 to 8.3940
Osmolarity
The infusion solution is iso-osmotic,3940 having an osmolarity of approximately 315 mOsm/L.3941
Trade Name(s)
Diflucan
Fluconazole is administered by intravenous infusion at a rate not exceeding 200 mg/hr.3940
Intact containers of fluconazole infusion solution should be stored at controlled room temperature and protected from excessive heat and freezing.3940 Do not remove moisture barrier overwrap until ready for use.3940 Solutions should be visually inspected for particulate matter and discoloration prior to administration; do not use if the solution is cloudy or precipitated.3940
Elastomeric Reservoir Pumps
Fluconazole (Pfizer) 2 mg/mL in sodium chloride 0.9% was evaluated for binding to natural rubber elastomeric reservoirs (Baxter). Less than 2% binding was found after storage for 2 weeks at 35°C with gentle agitation.2014
Central Venous Catheter
Fluconazole (Roerig) 2 mg/mL in dextrose 5% was found to be compatible with the ARROWg+ard Blue Plus (Arrow International) chlorhexidine-bearing triple-lumen central catheter. Essentially complete delivery of the drug was found with little or no drug loss occurring. Furthermore, chlorhexidine delivered from the catheter remained at trace amounts with no substantial increase due to the delivery of the drug through the catheter.2335
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