AHFS Class:

40:12 Replacement Preparations

Hydroxyethyl starch 130/0.4 is available as a 6% (6 g/100 mL) injection in sodium chloride 0.9% in 500-mL plastic containers.³⁴⁵³ The solution also contains sodium hydroxide or hydrochloric acid for pH adjustment.³⁴⁵³

pH

From 4 to 5.5.³⁴⁵³

Osmolarity

The calculated osmolarity is 308 mOsm/L.³⁴⁵³

Tonicity

The injection is an isotonic solution.³⁴⁵³

Sodium Content

The product provides 77 mEq of sodium per 500-mL container.³⁴⁵³

Trade Name(s)

Voluven

Hydroxyethyl starch 130/0.4 6% in sodium chloride 0.9% is administered only by intravenous infusion.³⁴⁵³ Any remaining solution in partially used containers should be discarded.³⁴⁵³ The dosage and rate of infusion should be individualized according to the patient’s condition and response.³⁴⁵³ The container is made of nondiethylhexyl phthalate (non-DEHP) plastic and is latex free.³⁴⁵³ The container itself does not require a vented intravenous administration set, and the manufacturer states that administration of the drug should not be vented.³⁴⁵³ The product should be inspected for discoloration and particulate matter prior to use.³⁴⁵³ If the drug is administered by pressure infusion, air should be withdrawn or expelled from the container through the medication/administration port prior to infusion.³⁴⁵³

Hydroxyethyl starch 130/0.4 6% in sodium chloride 0.9% is a clear to slightly opalescent colorless to slightly yellow colloidal solution.³⁴⁵³ The product should be stored at 15 to 25°C and should not be frozen.³⁴⁵³ The bag of solution should not be removed from the overwrap until immediately prior to use.³⁴⁵³ It should only be administered if the solution is clear and free from particles.³⁴⁵³ The solution should be administered immediately after insertion of the administration set.³⁴⁵³

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions September 30, 2019. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.