Eptifibatide is available at a concentration of 2 mg/mL in 10- and 100-mL vials and at a concentration of 0.75 mg/mL in 100-mL vials.3048 Each mL of injection also contains citric acid 5.25 mg and sodium hydroxide to adjust the pH.3048
pH
The pH is adjusted to near 5.35 during manufacturing.3048
Trade Name(s)
Integrilin
Eptifibatide is administered by intravenous bolus (push) injection; the appropriate dose should be withdrawn from the 10-mL vial.3048 The bolus dose should be followed immediately by a continuous intravenous infusion; using an infusion pump, the appropriate concentration of eptifibatide in a 100-mL vial should be spiked with a vented infusion set and administered directly (undiluted) at a rate that is appropriate for the specific patient.3048 For some indications, a second bolus injection of eptifibatide is administered 10 minutes after the initial bolus.3048
Intact vials of eptifibatide should be stored under refrigeration and protected from light until the time of administration.3048 The drug may be stored for up to 2 months at room temperature; the cartons of the vials stored at room temperature should be marked with a “DISCARD BY” date of 2 months after transfer to room temperature storage or the expiration date, whichever comes first.3048
pH Effects
The minimum rate of decomposition occurs in the pH range of 5 to 6.2417
Y-Site Injection Compatibility (1:1 Mixture)
Additional Compatibility Information
Other Drugs
The manufacturer states that eptifibatide may be administered in the same intravenous administration line as alteplase, atropine, dobutamine, heparin, lidocaine, meperidine, metoprolol, midazolam, morphine, nitroglycerin, and verapamil.3048
Furosemide
Eptifibatide must not be administered in the same intravenous administration line as furosemide.3048 Admixtures of eptifibatide and furosemide demonstrated precipitation and crystal formation 1 hour after mixing.3049
For a list of references cited in the text of this monograph, search the monograph titled References.