AHFS Class:

91:32.04 GABA-mediated Benzodiazepine Antidotes

Generic Name

• Flumazenil (CAS Registry Number: 78755-81-4)

Flumazenil is available as a 0.1-mg/mL solution in 5- and 10-mL multiple-dose vials.³⁰²⁰ Each mL also contains methylparaben 1.8 mg, propylparaben 0.2 mg, sodium chloride 0.9%, edetate disodium 0.01%, and acetic acid 0.01%.³⁰²⁰ The pH is adjusted with hydrochloric acid and, if necessary, sodium hydroxide.³⁰²⁰

pH

Approximately 4.³⁰²⁰

Trade Name(s)

Romazicon

Flumazenil is administered intravenously over 15 to 30 seconds.³⁰²⁰ To minimize pain at the injection site, flumazenil should be administered through a freely running intravenous infusion line into a large vein.³⁰²⁰ Extravasation may result in local irritation.³⁰²⁰

Intact vials should be stored at controlled room temperature.³⁰²⁰ Discard the product 24 hours after removal from its original vial, whether drawn into a syringe or admixed in an infusion solution.³⁰²⁰

Solution Compatibility

Additive Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions September 12, 2025. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.