AHFS Class:

28:12.92 Anticonvulsants, Miscellaneous

Generic Name

• CarBAMazepine (CAS Registry Number: 298-46-4)

Carbamazepine is available as a 10-mg/mL concentrate for injection in 20-mL single-dose vials.³³¹⁸ Each mL of the concentrate also contains betadex sulfobutyl ether sodium 250 mg and sodium phosphate monobasic dihydrate 0.78 mg in water for injection and may contain sodium hydroxide and/or hydrochloric acid for pH adjustment.³³¹⁸ The concentrate must be diluted prior to administration.³³¹⁸

pH

Carbamazepine 10-mg/mL concentrate for injection has an adjusted pH of 6.2.³³¹⁸

Trade Name(s)

Carnexiv

Carbamazepine concentrate for injection is administered by intravenous infusion over 30 minutes following dilution of the appropriate dose in 100 mL of a compatible infusion solution.³³¹⁸

Carbamazepine concentrate for injection is a clear, colorless solution.³³¹⁸ Intact vials should be stored at controlled room temperature.³³¹⁸ Vials are for single-dose only; any unused portion should be discarded.³³¹⁸

Carbamazepine concentrate for injection diluted in a compatible infusion solution may be stored for 4 hours at 20 to 25°C or 24 hours at 2 to 8°C.³³¹⁸ Carbamazepine solution should be visually inspected prior to administration; if particulate matter is present or if cloudiness or discoloration occurs, the solution should be discarded.³³¹⁸

Solution Compatibility

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions March 31, 2024. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.