AHFS Class:

24:08.16 Direct Vasodilators

Fenoldopam mesylate is available as a concentrate for injection in 1- and 2-mL single-use ampuls.³²⁴¹ Each mL of the concentrate for injection contains fenoldopam 10 mg (as the mesylate salt), propylene glycol 518 mg, citric acid 3.44 mg, sodium citrate dihydrate 0.61 mg, and sodium metabisulfite 1 mg.³²⁴¹ The concentrate must be diluted for use.³²⁴¹

To prepare a diluted solution of fenoldopam for continuous intravenous infusion in adult patients, 1, 2, or 4 mL of the concentrate for injection should be added to 250, 500, or 1000 mL, respectively, of sodium chloride 0.9% or dextrose 5% to yield a solution with a fenoldopam concentration of 40 mcg/mL.³²⁴¹

To prepare a diluted solution for continuous intravenous infusion in pediatric patients, 0.6, 1.5, or 3 mL of the concentrate for injection should be added to 100, 250, or 500 mL, respectively, of sodium chloride 0.9% or dextrose 5% to yield a solution with a fenoldopam concentration of 60 mcg/mL.³²⁴¹

Trade Name(s)

Corlopam

Fenoldopam mesylate is administered by continuous intravenous infusion only after dilution in dextrose 5% or sodium chloride 0.9%.³²⁴¹

Intact ampuls should be stored at 2 to 30°C.³²⁴¹ After dilution in dextrose 5% or sodium chloride 0.9%, fenoldopam mesylate is stable for 4 hours at room temperature or 24 hours when refrigerated prior to administration.³²⁴¹

Solutions should be visually inspected for particulate matter and discoloration prior to administration; if particulate matter is present or cloudiness occurs, the solution should be discarded.³²⁴¹

Solution Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions September 12, 2024. © Copyright, 2024. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.