AHFS Class:

10:00 Antineoplastic Agents

Generic Name

• Avelumab (CAS Registry Number: 1537032-82-8)

Avelumab is available as a 20-mg/mL concentrate for injection in 10-mL preservative-free, single-dose vials containing 200 mg of the drug.³⁸⁸² Each mL of the concentrate contains avelumab 20 mg with D-mannitol 51 mg, glacial acetic acid 0.6 mg, polysorbate 20 0.5 mg and sodium hydroxide 0.3 mg in water for injection.³⁸⁸²

The concentrate must be diluted prior to administration.³⁸⁸² To prepare the drug for intravenous infusion, the appropriate dose of the concentrate should be withdrawn from the vial and added to an infusion bag containing 250 mL of sodium chloride 0.9% or sodium chloride 0.45%.³⁸⁸² The solution should be mixed by gentle inversion and should not be shaken.³⁸⁸² Any unused portion remaining in vials should be discarded.³⁸⁸²

pH

5 to 5.6.³⁸⁸²

Trade Name(s)

Bavencio

Avelumab is administered by intravenous infusion over 60 minutes only after dilution in sodium chloride 0.9% or sodium chloride 0.45%.³⁸⁸² Diluted solutions for infusion should be administered through a 0.2-µm low protein-binding inline filter.³⁸⁸²

Other drugs should not be co-administered with avelumab through the same infusion line.³⁸⁸²

Intact vials of avelumab should be stored at 2 to 8°C in the original carton to protect from light and should not be shaken or frozen.³⁸⁸² The concentrate for injection is a clear, colorless to slightly yellow solution.³⁸⁸² Vials should be visually inspected for particulate matter and discoloration prior to use; discard the solution if it is discolored, cloudy, or if particulate matter is present.³⁸⁸²

The manufacturer states diluted solutions should be protected from light and may be stored for no more than 4 hours at room temperature or 24 hours at 2 to 8°C.³⁸⁸² Refrigerated solutions should be allowed to come to room temperature prior to administration.³⁸⁸² Diluted solutions should not be frozen or shaken.³⁸⁸²

Filtration

Diluted solutions for infusion should be administered through a 0.2-µm low protein-binding inline filter.³⁸⁸²

Solution Compatibility

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions March 23, 2023. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.