Micafungin sodium is available in vials containing 50 and 100 mg of drug with lactose 200 mg and citric acid and/or sodium hydroxide added during manufacturing to adjust pH.2893 Reconstitute the 50- or 100-mg vials with 5 mL of sodium chloride 0.9% or dextrose 5%, resulting in solutions containing micafungin sodium 10 or 20 mg/mL, respectively.2893 Diluents containing a bacteriostatic agent should not be used for reconstitution.2893 To minimize foaming, gently swirl the vials to dissolve the contents.2893 Do not shake vigorously.2893
pH
From 5 to 7.2893
Trade Name(s)
Mycamine
Micafungin sodium is diluted in 100 mL of sodium chloride 0.9% or dextrose 5% and administered by intravenous infusion over 1 hour.2893 Existing infusion lines should be flushed with sodium chloride 0.9% prior to starting the micafungin sodium infusion.2893
Store intact vials at controlled room temperature.2893 When reconstituted as directed, the manufacturer indicates that micafungin sodium is stable for up to 24 hours at room temperature in the original container.2893 However, the drug does not contain a preservative, and the manufacturer recommends discarding partially used vials.2893 Micafungin sodium diluted for infusion is stable for up to 24 hours at room temperature when protected from light.2893
Light Effects
The manufacturer states that micafungin sodium dilutions should be protected from light but that covering tubing and drip chambers is not necessary.2893
Syringes
Micafungin sodium (Astellas) reconstituted with and further diluted in sodium chloride 0.9% to a concentration of 0.5 or 1 mg/mL and stored in 3 different polypropylene syringes demonstrated physical and chemical stability for 15 days stored at 25°C with 60% relative humidity in the dark.3273
For a list of references cited in the text of this monograph, search the monograph titled References.