AHFS Class:

8:14.16 Echinocandins

Micafungin sodium (Astellas) is available as a lyophilized powder in single-dose vials containing 50 or 100 mg of micafungin (equivalent to micafungin sodium 50.86 or 101.73 mg, respectively) with lactose monohydrate 200 mg and citric acid and/or sodium hydroxide for pH adjustment.²⁸⁹³

Micafungin sodium (Endo) is available as a lyophilized powder in single-dose vials containing 50 or 100 mg of micafungin (equivalent to micafungin sodium 50.86 or 101.73 mg, respectively) with sucrose as an excipient.⁴⁰⁸³ Each 50- or 100-mg vial also contains sucrose 200 or 400 mg, respectively and citric acid and/or sodium hydroxide for pH adjustment.⁴⁰⁸³

Reconstitute the 50- or 100-mg vials with 5 mL of sodium chloride 0.9% or dextrose 5% to yield a solution containing micafungin 10 or 20 mg/mL, respectively.²⁸⁹³; ⁴⁰⁸³ Diluents containing a bacteriostatic agent should not be used for reconstitution.²⁸⁹³; ⁴⁰⁸³ To minimize foaming, gently swirl the vial to dissolve the contents.²⁸⁹³; ⁴⁰⁸³ Do not shake vigorously.²⁸⁹³ The reconstituted solution should be further diluted prior to administration.²⁸⁹³

To prepare a solution for infusion, the reconstituted solution should be diluted in sodium chloride 0.9% or dextrose 5%.²⁸⁹³; ⁴⁰⁸³ Adult doses should be diluted in 100 mL of infusion solution.²⁸⁹³; ⁴⁰⁸³ Pediatric doses should be diluted in an infusion bag or syringe to yield a final concentration between 0.5 to 4 mg/mL.²⁸⁹³; ⁴⁰⁸³ Concentrations exceeding 1.5 mg/mL should be labeled for administration through a central catheter.²⁸⁹³; ⁴⁰⁸³

Micafungin sodium also is available as a premixed, ready-to-use 1 mg/mL solution in sodium chloride 0.9% in 50- 100- or 150-mL single-dose flexible plastic containers for intravenous infusion.⁴⁰⁸⁴ Each 50-mL of the ready-to-use solution for infusion contains micafungin 50 mg (equivalent to micafungin sodium 50.87), citric acid anhydrous 36 mg, sodium chloride 450 mg, and sodium citrate dihydrate 92 mg.⁴⁰⁸⁴ The ready-to-use solution for infusion is intended for use in patients requiring micafungin doses of 50, 100, or 150 mg only.⁴⁰⁸⁴

pH

Reconstituted solution using sodium chloride 0.9%: 5 to 7 (Astellas) or 4.5 to 7 (Endo).²⁸⁹³; ⁴⁰⁸³

Premixed, ready-to-use solution: 4.5 to 5.1.⁴⁰⁸⁴

Trade Name(s)

Mycamine

Micafungin sodium is administered by intravenous infusion over 1 hour.²⁸⁹³; ⁴⁰⁸³; ⁴⁰⁸⁴ Concentrations exceeding 1.5 mg/mL should be administered through a central catheter to decrease the risk of infusion reactions.²⁸⁹³; ⁴⁰⁸³ Existing infusion lines should be flushed with sodium chloride 0.9% prior to starting the micafungin sodium infusion.²⁸⁹³; ⁴⁰⁸³; ⁴⁰⁸⁴

Micafungin sodium is a white lyophilized powder.²⁸⁹³; ⁴⁰⁸³ Intact vials of the powder should be stored at controlled room temperature.²⁸⁹³; ⁴⁰⁸³

Reconstituted solutions should be protected from light and may be stored at 25°C in the original vial for up to 24 hours (Astellas) or 12 hours (Endo).²⁸⁹³; ⁴⁰⁸³

Diluted solutions should be protected from light and may be stored at 25°C for up to 24 hours (Astellas) or 12 hours (Endo).²⁸⁹³; ⁴⁰⁸³ Product labeling for micafungin sodium (Endo) states that the total time from reconstitution to completion of infusion should not exceed 12 hours at controlled room temperature.⁴⁰⁸³

Micafungin sodium ready-to-use solution for infusion is a clear, colorless solution.⁴⁰⁸⁴ Intact containers of the ready-to-use solution should be stored at 2 to 8°C in the original carton to protect from light.⁴⁰⁸⁴ Do not freeze.⁴⁰⁸⁴ If necessary, intact containers may be stored at room temperature (20 to 25°C) in the original carton for up to 30 days.⁴⁰⁸⁴ Once stored at room temperature, do not place back in the refrigerator.⁴⁰⁸⁴ Discard micafungin ready-to-use solution after 30 days if stored at room temperature.⁴⁰⁸⁴ Micafungin ready-to-use solution for infusion does not require light protection during administration.⁴⁰⁸⁴

Light Effects

Micafungin sodium is light sensitive.²⁸⁹³; ⁴⁰⁸³ Reconstituted solutions and diluted solutions should be protected from light but product labeling states that covering tubing and drip chambers is not necessary.²⁸⁹³; ⁴⁰⁸³

Micafungin ready-to-use solution for infusion does not require light protection during administration.⁴⁰⁸⁴

Syringes

Micafungin sodium (Astellas) reconstituted with and further diluted in sodium chloride 0.9% to a concentration of 0.5 or 1 mg/mL and stored in 3 different polypropylene syringes demonstrated physical and chemical stability for 15 days stored at 25°C with 60% relative humidity in the dark.³²⁷³

Solution Compatibility

Additive Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions March 31, 2024. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.