Verapamil hydrochloride is available as a 2.5-mg/mL injection solution in 2- and 4-mL single-dose, preservative-free vials.3775 Each mL contains verapamil hydrochloride 2.5 mg with sodium chloride 8.5 mg in water for injection.3775 Hydrochloric acid and/or sodium hydroxide is used to adjust the pH.3775
pH
From 4 to 6.5.3775
Osmolality
The osmolality of verapamil hydrochloride 2.5 mg/mL was determined to be 290 mOsm/kg.1233
Verapamil hydrochloride injection is administered by slow intravenous injection.3775 Direct intravenous injection should be performed over at least 2 minutes and at least 3 minutes in older patients.3775 Intravenous infusion has also been performed.4
Verapamil hydrochloride injection is a clear, colorless solution.3775 Intact vials should be stored at controlled room temperature and in the original carton to protect from light until time of use.3775 Freezing should be avoided.4
Verapamil hydrochloride under simulated summer conditions in paramedic vehicles was exposed to temperatures ranging from 26 to 38°C over 4 weeks. Analysis found no loss of the drug under these conditions.2562
Verapamil hydrochloride injection is physically compatible and chemically stable for at least 24 hours in most common large volume parenteral solutions when stored at 25°C protected from light; however, dilution of verapamil hydrochloride injection in sodium lactate injection in polyvinyl chloride (PVC) bags is not recommended due to stability concerns.3775
pH Effects
Verapamil hydrochloride precipitates in solutions with a pH greater than 6.3775
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