AHFS Class:

56:22.12 Dopamine Receptor Antagonists

Generic Name

• DroPERidol (CAS Registry Number: 548-73-2)

Droperidol is available in 1- and 2-mL ampuls and vials.²⁹⁰⁶; ²⁹⁰⁷ Each mL of solution contains droperidol 2.5 mg with lactic acid and, if necessary, sodium hydroxide²⁹⁰⁷ to adjust the pH.²⁹⁰⁶; ²⁹⁰⁷

pH

From 3 to 3.8.²⁹⁰⁶; ²⁹⁰⁷

Osmolality

The osmolality of droperidol 2.5 mg/mL was determined to be 16 mOsm/kg.¹²³³

Droperidol may be administered intramuscularly or slowly intravenously.²⁹⁰⁶; ²⁹⁰⁷

Intact ampuls and vials of droperidol should be stored at controlled room temperature and retained in the original container to protect from light.²⁹⁰⁶; ²⁹⁰⁷

Precipitation may occur if droperidol is mixed with barbiturates.⁴

Syringes

The stability of droperidol 2.5 mg/mL repackaged in polypropylene syringes was evaluated. Little change in concentration was found after 4 weeks at room temperature out of direct light.²¹⁶⁴

Central Venous Catheter

Droperidol (Abbott) 0.4 mg/mL in dextrose 5% was found to be compatible with the ARROWg+ard Blue Plus (Arrow International) chlorhexidine-bearing triple-lumen central catheter. Essentially complete delivery of the drug was found with little or no drug loss occurring. Furthermore, chlorhexidine delivered from the catheter remained at trace amounts with no substantial increase due to the delivery of the drug through the catheter.²³³⁵

Solution Compatibility

Additive Compatibility

Drugs in Syringe Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions December 5, 2024. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.