AHFS Class:

24:28.08 Dihydropyridines

Generic Name

• Clevidipine

Clevidipine is available as a ready-to-use oil-in-water emulsion in 50- and 100-mL single-dose vials.³²⁰⁰ Each mL contains clevidipine 0.5 mg along with soybean oil 200 mg, glycerin 22.5 mg, purified egg yolk phospholipids 12 mg, oleic acid 0.3 mg, and disodium edetate 0.05 mg (0.005%) with sodium hydroxide to adjust the pH.³²⁰⁰

pH

6 to 8.³²⁰⁰

Trade Name(s)

Cleviprex

Clevidipine is administered by intravenous infusion into either a central line or peripheral line using an infusion device that allows calibrated infusion rates.³²⁰⁰

Vials of clevidipine should be inverted gently several times prior to administration to ensure uniformity of the emulsion.³²⁰⁰ Commercially available standard plastic cannulae may be used to administer the infusion.³²⁰⁰

Clevidipine ready-to-use emulsion should not be diluted.³²⁰⁰

Clevidipine is a milky white, oil-in-water emulsion.³²⁰⁰ Intact vials should be stored at 2 to 8°C in the carton to protect from light and should not be frozen.³²⁰⁰ Intact vials may be stored for up to 2 months at controlled room temperature; vials stored at room temperature should be marked with the date of removal from refrigeration and should be discarded 2 months after the date of transfer to room temperature storage or the expiration date, whichever comes first.³²⁰⁰ Once moved to storage at room temperature, vials should not be returned to refrigerated storage.³²⁰⁰

The lipid base of the oil-in-water emulsion supports microbiological growth.³²⁰⁰ The disodium edetate in the formulation retards the growth of microorganisms, but the product can still support growth and is not antimicrobially preserved.³²⁰⁰ Aseptic technique should be maintained during handling.³²⁰⁰

Once the vial stopper is punctured, administration of clevidipine should be completed within 12 hours and any unused portion should be discarded.³²⁰⁰ The emulsion should be visually inspected for particulate matter and discoloration prior to administration.³²⁰⁰

Temperature Effects

Clevidipine should be stored at 2 to 8°C;³²⁰⁰ however, clevidipine (Chiesi) 0.5 mg/mL in intact vials has been reported to be physically and chemically stable after 5 cycles of alternating storage at 5°C for 24 hours followed by 25°C for 24 hours.³³³⁴

Freezing Solutions

Clevidipine should not be frozen;³²⁰⁰ however, clevidipine (Chiesi) 0.5 mg/mL in intact vials has been reported to be physically and chemically stable for up to 12 hours at -15°C followed by storage for 24 hours at 5°C.³³³⁴

Light Effects

Clevidipine is photosensitive and should be stored protected from light; however protection from light during administration is not required.³²⁰⁰

Standardize 4 Safety

One or more standardized concentrations for this drug have been established through Standardize 4 Safety (S4S), a national patient safety initiative to reduce medication errors, especially during transitions of care. (See Standardize 4 Safety in Users Guide.) Recommendations developed to date through this initiative are available at www.ashp.org/pharmacy-practice/standardize-4-safety-initiative.

Table 1. Standardize 4 Safety Continuous IV Infusion Standard Concentrations for Clevidipine³⁶³⁵

Y-Site Injection Compatibility (1:1 Mixture)

For a list of references cited in the text of this monograph, search the monograph titled References.

ASHP^® Injectable Drug Information^TM. Selected Revisions September 12, 2024. © Copyright, 2025. American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.