Doxapram hydrochloride is available in 20-mL multiple-dose vials.3220 Each mL of solution contains doxapram hydrochloride 20 mg and benzyl alcohol 0.9% in water for injection.3220
Infusions of doxapram may be prepared by transferring 12.5 mL (250 mg) of doxapram hydrochloride to an infusion bag containing 250 mL of dextrose 5%, dextrose 10%, or sodium chloride 0.9% or adding 20 mL (400 mg) of doxapram hydrochloride to 180 mL of dextrose 5%, dextrose 10%, or sodium chloride 0.9%; the concentration to be prepared is dependent upon the indication.3220
pH
The pH of the undiluted injection ranges from 3.5 to 5.3220
Trade Name(s)
Dopram
Doxapram hydrochloride is administered by intravenous injection or by intravenous infusion following dilution in a compatible infusion solution.3220
Doxapram hydrochloride is a clear, colorless solution.3220 Intact vials of doxapram hydrochloride injection should be stored at controlled room temperature.3220
pH Effects
Doxapram hydrochloride in solution became turbid when the pH was adjusted from 3.8 to 5.7 with 0.1 N sodium hydroxide.1177 When the pH was adjusted down to 1.9 with 0.1 N hydrochloric acid, no visible change occurred to the clear solution.1177 The drug is stated to be incompatible with alkaline drugs.3220
At pH 2.5 to 6.5, doxapram hydrochloride remained chemically stable for 24 hours.1177 At pH 7.5 and above, a 10 to 15% doxapram hydrochloride loss occurred in about 6 hours.1177
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