[Arnold Pick (1851–1924), professor of psychiatry and neurology at the German University in Prague]

= FRONTOTEMPORAL DEMENTIA

= rare form of presenile dementia similar to Alzheimer disease; may be inherited with autosomal dominant mode; M <F

• social impairment + disinhibitive and impulsive behavior
• focal cortical atrophy of anterior frontal + anterior temporal lobes
• dilatation of frontal + temporal horns of lateral ventricle

PET:

• hypometabolism in frontal + anterior temporal lobes + anterior cingulate gyrus
• temporal lobe involvement extends to anterior aspects (NOT in Alzheimer disease)
• frontal-predominant form = sparing of temporal lobes