= BILATERAL STRIOPALLIDODENTATE CALCINOSIS = FAMILIAL CEREBROVASCULAR FERROCALCINOSIS

= rare neurodegenerative disease characterized by bilateral symmetric deposition of calcium + other minerals in basal ganglia, thalamus, dentate nucleus, centrum semiovale

• slow onset of headaches, vertigo, movement disorder, syncope, seizures, paresis, spasticity, gait disturbance, speech disorder
• coma, dementia, Parkinsonism, chorea, tremor
• dystonia, myoclonia, orthostatic hypotension
• NO hypoparathyroidism

Affected area: basal ganglia, dentate nucleus, thalamus, cerebral subcortical white matter

• bilaterally symmetric hyperdense + T1-hyperintense calcifications

DDx: hypoparathyroidism, pseudohypoparathyroidism, pseudopseudohypoparathyroidism