[J. C. P. Williams (1900–????), New Zealand cardiologist]

= IDIOPATHIC HYPERCALCEMIA OF INFANCY

• peculiar elfinlike facies, dysplastic dentition
• neonatal hypercalcemia (not in all patients)
• mental + physical retardation
• Skeletal manifestations
  • osteosclerosis ← trabecular thickening
  • dense broad zone of provisional calcification
  • radiolucent metaphyseal bands
  • dense vertebral end plates + acetabular roofs
  • bone islands in spongiosa
  • metastatic calcification
  • craniostenosis
• Cardiovascular manifestations
  • supravalvular aortic stenosis (33%), aortic hypoplasia
  • valvular + peripheral pulmonary artery stenosis
  • ASD, VSD
  • stenoses of major vessels (innominate, carotids, renal aa.)
• GI and GU tract:
  • colonic diverticula
  • bladder diverticula

Prognosis: spontaneous resolution after 1 year in most

Rx: withhold vitamin D + calcium

DDx: Hypervitaminosis D