= DISSEMINATED LIPOGRANULOMATOSIS

Histo: foam cell granulomas; lipid storage of neuronal tissue (accumulation of ceramide + gangliosides)

• hoarse weak cry; subcutaneous + periarticular granulomas
• swelling of extremities; generalized joint swelling
• intermittent fever, dyspnea; lymphadenopathy
• capsular distension of multiple joints (hand, elbow, knee)
• juxtaarticular bone erosions from soft-tissue granulomas
• subluxation / dislocation
• disuse / steroid deossification

Prognosis: death from respiratory failure within 2 years