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Differential Diagnosis of Musculoskeletal Disorders

Bone Overdevelopment!!navigator!!

  1. Marfan syndrome
  2. Klippel-Trénaunay syndrome
  3. Nerve territory-oriented macrodactyly
    1. Macrodystrophia lipomatosa
    2. Fibrolipomatous hamartoma with macrodactyly

Erlenmeyer Flask Deformity!!navigator!!

= expansion of distal end of long bones, usually femur

  1. Gaucher disease, Niemann-Pick disease
  2. Hemolytic anemia: thalassemia, sickle cell
  3. Osteopetrosis
  4. Heavy metal poisoning
  5. Metaphyseal dysplasia = Pyle disease
  6. Rickets
  7. Fibrous dysplasia
  8. Down syndrome
  9. Achondroplasia
  10. Rheumatoid arthritis
  11. Hypophosphatasia
  12. Leukemia

mnemonic: TOP DOG

  • Thalassemia
  • Osteopetrosis
  • Pyle disease
  • Diaphyseal aclasis
  • Ollier disease
  • Gaucher disease

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