| Drug | Seizure Type | Therapeutic Blood Level (µg/mL) | Side Effects |
|---|---|---|---|
| Phenobarbital | Generalized | 15–35 | Sedation |
| Increased drug metabolism | |||
| Valproate | Generalized | 50–100 | Pancreatitis |
| Absence | Hepatic dysfunction | ||
| Thrombocytopenia | |||
| Felbamate | Generalized | Insomnia | |
| Partial | Ataxia | ||
| Nausea | |||
| Phenytoin | Generalized | 10–20 | Gingival hyperplasia |
| Partial | Dermatitis | ||
| Resistance to nondepolarizing muscle relaxants | |||
| Fosphenytoin | Generalized | Paresthesias | |
| Partial | Hypotension | ||
| Carbamazepine | Generalized | 6–12 | Cardiotoxicity |
| Partial | Hepatitis | ||
| Resistance to nondepolarizing muscle relaxants | |||
| Lamotrigine | Generalized | 2–16 | Rash |
| Partial | Stevens-Johnson syndrome | ||
| Topiramate | Generalized | 4–10 | Severe metabolic acidosis |
| Partial | Hyperthermia | ||
| Gabapentin | Generalized | 4–16 | Fatigue |
| Partial | Somnolence | ||
| Primidone | Generalized | 6–12 | Nausea |
| Partial | Ataxia | ||
| Clonazepam | Absence | 0.01–0.07 | Ataxia |
| Ethosuximide | Absence | 40–100 | Leukopenia |
| Levetiracetam | Generalized | 5–45 | Erythema multiforme |
| Partial | Dizziness | ||
| Headache | |||
| Oxcarbazepine | Partial | 10–35 | Hyponatremia |
| Diplopia | |||
| Somnolence | |||
| Tiagabine | Partial | Tremor | |
| Depression | |||
| Zonisamide | Generalized | 10–40 | Anorexia |
| Decreased cognition |