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Topic Outline

Anesthetic drugs are administered with the goal of rapidly establishing and maintaining a therapeutic effect while minimizing undesired side effects (Gupta DK, Henthorn TK. Basic principles of clinical pharmacology. In: Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Ortega R, Stock MC, eds.Clinical Anesthesia. Philadelphia: Lippincott Williams & Wilkins; 2013: 156–188).


  1. Pharmacokinetic Principles: Drug Absorption and Routes of Administration
  2. Drug Distribution
  3. Drug Elimination
  4. Pharmacokinetic Models
  5. Compartmental Pharmacokinetic Models
  6. Pharmacodynamic Principles
  7. Drug–Receptor Interactions
  8. Drug Interactions
  9. Clinical Applications of Pharmacokinetic and Pharmacodynamics to the Administration of IV Anesthetics