| Patient Status | Volume of Distribution (L/kg) | Clearance (mL/kg/min) | Elimination Half-Time (min) | |
|---|---|---|---|---|
| Neostigmine | Normal | 0.7 | 9.2 | 177 |
| Renal failure | 1.6 | 7.8 | 181 | |
| Edrophonium | Normal | 1.1 | 9.6 | 110 |
| Renal failure | 0.7 | 2.7 | 206 | |
| Pyridostigmine | Normal | 1.1 | 8.6 | 112 |
| Renal failure | 1.0 | 2.1 | 379 |