| Warfarin | Dabigatran | Apixaban | Rivaroxaban | |
|---|---|---|---|---|
| Target | Vitamin K | Thrombin | Factor Xa | Factor Xa |
| Time to peak (hr) | 72–96 | 1–2 | 3 | 2.5–4 |
| Half-life (hr) Dose (mg) Frequency Metabolism Drug interactions | 40 2–10 Daily or every other day None CYP2C9 | 9–13 150 Once or twice daily Renal excretion Few | 8–15 5 Twice daily Hepatic CYP3A4 | 7–11 20 Daily Hepatic CYP3A4 |