| Stable patients without evidence of bleeding or coagulopathy | <10,000/µL |
| Prophylaxis for invasive procedure such as lumbar puncture, neuraxial anesthesia, central venous catheterization, endoscopy with biopsy, liver biopsy, or major surgery | <50,000/µL |
| Stable patients with clinical evidence of bleeding or coagulopathy | <50,000/µL |
| Patients with DIC and signs of ongoing bleeding | <50,000/µL |
| Patients undergoing massive transfusion | <75,000/µL |
| Patients having surgery at critical sites such as the eye or CNS | <100,000/µL |
| Microvascular bleeding attributed to platelet dysfunction such as uremia, liver disease, or after CPB | Clinician judgment |
CNS = central nervous system; CPB = cardiopulmonary bypass; DIC = disseminated intravascular coagulation.