| Advantages | Disadvantages | |
|---|---|---|
| Colloid | Smaller volume infused | Greater cost |
| Prolonged increase in plasma volume | Coagulopathy (dextran > hetastarch) | |
| Greater peripheral edema | Pulmonary edema (capillary leak states) | |
| Less cerebral edema | Decreased glomerular filtration rate | |
| Osmotic diuresis (low-|molecular-weight dextran) | ||
| Crystalloid | Lower cost | Transient hemodynamic improvement |
| Greater urinary flow | Peripheral edema (protein dilution) | |
| Replaces interstitial fluid | Pulmonary edema (protein dilution plus high pulmonary artery occlusion pressure) |