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Definition

nicotinamide

(nikŏ-tiē'nă-mīd, tin'ă )

[nicotine + amide]

A basic amide that is a member of the vitamin B complex, used in the prophylaxis and treatment of pellagra. SYN: niacinamide.

n. adenine dinucleotide

ABBR: NAD

An enzyme important in accepting electrons in the course of metabolic reactions. In its oxidized form, NAD+ gives up its electron and is converted to the reduced form, NADH.SYN: V factor.

n. adenine dinucleotide-dehydrogenase

SEE: nicotinamide adenine dinucleotide phosphate.

n. adenine dinucleotide phosphate

ABBR: NADP

A coenzyme that contains adenosine, nicotinamide, and phosphoric acid. When in its oxidized form (NADP+), it serves as an electron carrier in catabolic and anabolic reactions. In its reduced form (NADPH or NADPH-diaphorase), it is important in reducing the ferric iron (Fe+++) to its ferrous (Fe++) form, thus converting methemoglobin (which is unable to transport oxygen) to hemoglobin (which can transport oxygen). Deficiency of NADPH-diaphorase causes congenital methemoglobinemia. SYN: methemoglobin reductase.