ABBR: GTD

Any of several neoplastic diseases of the fetal chorion, including complete and partial hydatidiform mole, chorioadenoma destruens, and choriocarcinoma. The disease is an abnormal growth of cells that would normally develop into the placenta. Villi form and grow into the endometrium; and , while most are benign, some are cancerous. Sudden rapid uterine enlargement and early second-trimester vaginal bleeding characterize all forms of GTD. Other common signs include hyperemesis gravidarum, pregnancy-induced hypertension before 24 weeks' gestation, vaginal discharge of hydropic vesicles, and an absence of fetal heart tones.

Treatment: Aggressive forms of GTD, e.g., choriocarcinoma, which can metastasize throughout the body, are treated with chemotherapy, radiation therapy, and surgery. Moles and chorioadenoma destruens are treated with prompt evacuation of the uterus.