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Evidence summaries

Gonadotropins for Ovarian Stimulation in Women with Infertility

Gonadotropins appear to improve live birth rate compared with anti-oestrogens or aromatase inhibitors for intrauterine insemination in women with infertility. Level of evidence: "B"

The certainty of the evidence is downgraded by imprecion (few events).

Summary

A Cochrane review [Abstract] 1 included 47 studies assessing gonadotropins for intrauterine insemination. Gonadotropins versus anti-oestrogens: Gonadotropins improved live birth rate (OR 1.37, 95% CI 1.05 to 1.79; I² = 30%; 5 studies, n=1924). Gonadotropins with GnRH antagonist versus gonadotropins alone: There was no significant difference in live birth rate (OR 1.5, 95% CI 0.52 to 4.39; I² = 81%; 3 studies, n=419). Aromatase inhibitors versus gonadotropins: Aromatase inhibitors had lower live birth rate (OR 0.49, 95% CI 0.34 to 0.71; I²=0%; 2 studies, n=651). None of the agents compared lead to significantly higher multiple pregnancy rates.

Clinical comments

Note

Date of latest search: 2021-12-15

    References

    • Cantineau AE, Rutten AG, Cohlen BJ. Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility. Cochrane Database Syst Rev 2021;(11):CD005356. [PubMed]

Primary/Secondary Keywords