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Evidence summaries

Magnesium for Acute Traumatic Brain Injury

Magnesium administration appears not to provide any benefit in patients with acute traumatic brain injury. Level of evidence: "B"

A Cochrane review [Abstract] 1 included 3 studies with a total of 574 subjects. Data on mortality were only available in one study; RR 1.48, 95% CI 1.00 to 2.19, test for overall effect: Z = 1.96 (P = 0.05). Glasgow Outcome Score at six months was described in the three studies; mean difference 0.02, 95% CI -0.38 to 0.041, test for overall effect: Z = 0.08 (P = 0.94).

    References

    • Arango MF, Bainbridge D. Magnesium for acute traumatic brain injury. Cochrane Database Syst Rev 2008;(4):CD005400. [PubMed]

Primary/Secondary Keywords