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Evidence summaries

Three- or Four-Drug Versus Two-Drug Antiretroviral Maintenance Regimens for HIV Infection

Combination of three or four antiviral drugs results in reduced rate of virologic failure. Level of evidence: "A"

A Cochrane review [Abstract] 1 included 4 trials. Maintenance therapies involving fewer than three drugs were associated with higher risk of virologic failure (OR 5.55, 95% CI 3.14 to 9.80).

    References

    • Rutherford GW, Sangani PR, Kennedy GE. Three- or four- versus two-drug antiretroviral maintenance regimens for HIV infection. Cochrane Database Syst Rev 2003;(4):CD002037. [PubMed]

Primary/Secondary Keywords